![]() Together you can weigh the benefits and risks of each treatment and decide whether a monoclonal antibody treatment is right for you. ![]() Some monoclonal antibody drugs carry a risk of internal bleeding.ĭiscuss your cancer treatment options with your health care provider. Serious sores can also occur on the tissue that lines your cheeks and gums (mucosa). Sores and rashes on your skin can lead to serious infections in some cases. Some monoclonal antibodies are associated with a higher risk of inflammatory lung disease. Certain monoclonal antibodies increase the risk of high blood pressure, congestive heart failure and heart attacks. You might need to stay at the treatment facility for a few hours for monitoring. Infusion reactions usually occur while treatment is being administered or soon after, so your health care team will watch you closely for a reaction. You may receive medicine to block an allergic reaction before you begin monoclonal antibody treatment. Severe allergy-like reactions can occur and, very rarely, lead to death. Serious, but rare, side effects of monoclonal antibody therapy may include: Flu-like signs and symptoms, including chills, fatigue, fever, and muscle aches and pains.Allergic reactions, such as hives or itching.In general, the more common side effects caused by monoclonal antibody drugs include: ![]() This connection may promote immune system attacks on the cancer cells. Some drugs combine two monoclonal antibodies, one that attaches to a cancer cell and one that attaches to a specific immune system cell. Similarly, some monoclonal antibodies are combined with a chemotherapy drug in order to deliver the treatment directly to the cancer cells while avoiding healthy cells. When a monoclonal antibody is combined with a small radioactive particle, it transports the radiation treatment directly to cancer cells and may minimize the effect of radiation on healthy cells. Because of a monoclonal antibody's ability to connect with a cancer cell, the antibody can be engineered as a delivery vehicle for other treatments. When some of these antibodies attach to a cell, a series of events inside the cell may cause it to self-destruct. Certain monoclonal antibodies may attack the cell more directly. Monoclonal antibodies can interfere with that process so that your immune system cells are allowed to work without controls against cancer cells. Your body keeps your immune system from being overactive by making proteins that control the activity of the immune system cells. Some monoclonal antibody drugs block protein-cell interactions necessary for the development of new blood vessels. In order for a cancerous tumor to grow and survive, it needs a blood supply. Some monoclonal antibodies block the connection between a cancer cell and proteins that promote cell growth - an activity that is necessary for cancer growth and survival. Some monoclonal antibodies can trigger an immune system response that can destroy the outer wall (membrane) of a cancer cell. Cancer cells that are coated in monoclonal antibodies may be more easily detected and targeted for destruction. Some immune system cells depend on antibodies to locate the target of an attack. A particular drug may actually function by more than one means. Monoclonal antibodies are designed to function in different ways.
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